Genome-wide identification of transcript start and end sites by transcript isoform sequencing
نویسندگان
چکیده
منابع مشابه
Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues
Most human genes generate multiple transcript isoforms. The differential expression of these isoforms can help specify cell types. Diverse transcript isoforms arise from the use of alternative transcription start sites, polyadenylation sites and splice sites; however, the relative contribution of these processes to isoform diversity in normal human physiology is unclear. To address this questio...
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متن کاملTranscript isoform differences across human tissues are predominantly driven by alternative start and termination sites of transcription
Most human genes have multiple transcription start and polyadenylation sites, as well as alternatively spliced exons. Although such transcript isoform diversity contributes to the differentiation between cell types, the importance of contributions from the different isoform generating processes is unclear. To address this question, we used 798 samples from the Genotype-Tissue Expression (GTEx) ...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2014
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2014.121